Yes. You get bound up and your intestines and colon rupture poisoning your body until your liver and the rest of your lower organs shut down and you die in horrible excruciating pain that even opioids won't mask.
4 is my normal starting dose, ya lightweight. No, you can't overdose on it without getting incredibly stoopid, the molecule is too large to pass through the blood/brain barrier. Good thing, too. Loperamide was discovered by researchers looking for a stronger alternative to fentanyl. Mindewe, fentanyl is so powerful that if you touched pure fentanyl powder with your fingertip, you would overdose from transdermal uptake of the drug... but researchers wanted something stronger. They found loperamide, which, chemically, should be roughly 200 times more potent than fentanyl... but the molecule is too large to get into the human nervous system. It does, however, affect the peristalsis of the intestinal tract, which make it an effective anti-diarrheal. Now you know........... the rest of the story. Funny story, heroin addicts are taking immodium by the bottleful as an alternative to methadone. It drastically reduces the cold turkey withdrawal symptoms. Now you know......... the rest of the rest of the story.