I run tubeless on all my bikes but imo it's better suited to lower pressures applications like mtb. They barely seal at road pressures but I use it for the feel and speed, not the flats. fwiw, the constraint to tyre size/volume is the frame, optimized to a rim/wheel system, but dictated by the road surface. Smoother = lower vol/narrower, courser = higher vol/wider. And let's not talk about hookless. Also latex leaks so you'll be pumping up more regularly. Interestingly, gatorskins are so slow rolling it's still faster to use a regular performance tyre in an iron man and stop to fix the flats with the 6-8 minutes you'll be further up the road.
I went pretty wide w/ my road setup in part to avoid having to run high pressures. I'm running 50 psi F&R on 30/32 GP5000S TR, but they measure out closer to 32/33 when mounted. Pre-race footage of Paris-Roubaix showed MvdP ran about 51 psi on 32mm Vittorias, and he is a much bigger guy than me (although I'm probably fatter). Before I went tubeless though, I had good experiences with Vittoria latex tubes (no flats), but maybe only a couple hundred miles since I split miles with a gravel bike.